What is a common cause of stomach and duodenal ulcers?

Infection with Helicobacter pylori is recognized as a primary cause of stomach and duodenal ulcers. This bacterium is capable of surviving in the acidic environment of the stomach by producing enzymes that neutralize stomach acid. Once it colonizes the stomach lining, it can lead to inflammation and damage to the mucosal barrier. This disruption increases the vulnerability of the stomach and duodenum to the corrosive effects of gastric acid, ultimately resulting in ulcer formation.

Understanding the role of Helicobacter pylori is crucial, as its eradication can lead to improved healing of ulcers and a decrease in recurrence. This emphasizes the importance of addressing the underlying infection in treatment plans for peptic ulcer disease. The association of H. pylori with ulcers has been supported by numerous studies, establishing it as a significant factor in the development of these gastrointestinal conditions.